Stability of 1% voriconazole solution in a constant-rate infusion pump for topical ocular delivery to horses

Stillwater -mechentel news – Voriconazole 1% solution is stable in the commercial glass vial when stored at controlled temperatures as high as 40 °C for up to 30 days. To establish the effect of storage in a constant-rate infusion (CRI) pump on the sterility and stability of voriconazole 1% solution, Smith KM et al. have prepared Nine vials of voriconazole (Vfend® I.V.) 1% solution. Approximately half of each solution was used to prime a commercially available CRI pump with attached subpalpebral lavage system (CRI/SPL unit) with the remaining solution stored in the commercial glass vial. Three CRI/SPL units and their three corresponding vials were stored at one of three temperatures: 23 °C, 33 °C, and 40 °C. The CRI pumps ran for 7 days, and the vials were stored for 30 days. Fungal and aerobic bacterial cultures were performed on the first and last day of the storage period for each vessel. Samples were obtained at regular intervals for determination of voriconazole concentration using high-performance liquid chromatography. The results showed that no bacterial or fungal contamination was identified in any solution at any time point. All solutions stored in the commercial glass vial remained stable throughout the study period. Multiple CRI/SPL units became blocked with crystallized voriconazole. There was a significant increase in voriconazole concentration after passage through the CRI/SPL units. This study demonstrated that Voriconazole 1% solution is not compatible for use in a CRI/SPL unit at temperatures between 23 and 40 °C.

Autors: Smith KM1, Maxwell L, Gull T, Payton ME, Gilmour MA., Correspondenz: 1Department of Veterinary Clinical Sciences, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK, 74078, USA., Study: Stability of 1% voriconazole solution in a constant-rate infusion pump for topical ocular delivery to horses.,Source: Vet Ophthalmol. 2014 Mar 7. doi: 10.1111/vop.12155. [Epub ahead of print], Web: http://onlinelibrary.wiley.com/doi/10.1111/vop.12155/abstract