SRBD1 may be a common susceptibility gene 
for glaucoma in humans and dogs

Kanagawa – mechentel news – The finding of the study from N. Kanemaki et al. seems to identify SRBD1 as a common susceptibility gene for glaucoma in humans and dogs. Glaucoma is a degenerative optic neuropathy that is associated with elevated intraocular pressure. Primary open angle glaucoma is the most common type of glaucoma in canines, and its highest incidence among dog breeds has been reported in Shiba-Inus, followed by Shih-Tzus. These breeds are known to have an abnormal iridocorneal angle and dysplastic prectinate ligament. However, the hereditary and genetic backgrounds of these dogs have not yet been clarified. In this study, published in the issue of september from PLoS One, the authors from theV eterinary Teaching Hospital, Azabu University, Sagamihara, Kanagawa, Japan, investigated the association between polymorphisms of the glaucoma candidate genes, SRBD1, ELOVL5, and ADAMTS10, and glaucoma in Shiba-Inus and Shih-Tzus. We analyzed 11 polymorphisms in these three genes using direct DNA sequencing. Three SRBD1 SNPs, rs8655283, rs22018514 and rs22018513 were significantly associated with glaucoma in Shiba-Inus, while rs22018513, a synonymous SNP in exon 4, showed the strongest association (P = 0.00039, OR = 3.03). Conditional analysis revealed that rs22018513 could account for most of the association of these SNPs with glaucoma in Shiba-Inus. In Shih-Tzus, only rs9172407 in the SRBD1 intron 1 was significantly associated with glaucoma (P = 0.0014, OR = 5.25). There were no significant associations between the ELOVL5 or ADAMTS10 polymorphisms and glaucoma in Shiba-Inus and Shih-Tzus. The results showed that SRBD1 polymorphisms play an important role in glaucoma pathology in both Shiba-Inus and Shih-Tzus. SRBD1 polymorphisms have also been associated with normal- and high-tension glaucomas in humans.the scientists anticipated that the nucleotide sequencing data from this study can be used in genetic testing to determine for the first time, the genetic status and susceptibility of glaucoma in dogs, with high precision. Moreover, canine glaucoma resulting from SRBD1 polymorphisms could be a useful animal model to study human glaucoma.

Autoren: Kanemaki N, Tchedre KT, Imayasu M, Kawarai S, Sakaguchi M, Yoshino A, Itoh N, Meguro A, Mizuki N. Korrespondenz: Nobuhisa Mizuki, Department of Ophthalmology, Yokohama City University School of Medicine, Yokohama, Kanagawa, Japan. E-Mail: mizunobu@med.yokohama-cu.ac.jp. Studie: Dogs and Humans Share a Common Susceptibility Gene SRBD1 for Glaucoma Risk. Quelle: PLoS One. 2013 Sep 11;8(9):e74372. doi: 10.1371/journal.pone.0074372. Web: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0074372.